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Neural Control of Steering in Walking Drosophila
(2020-01-21)
Steering is a fundamental component of orienting behavior. It can be guided by external sensory cues, internal drives, and goal directions stored in working memory. Steering behavior provides an opportunity to study how ...
Roles of the multifunctional protein Spn1 in transcription and chromatin biology
(2020-01-22)
Gene transcription by RNA polymerase II (RNAPII) is a tightly regulated process necessary for the development and growth of all eukaryotes. In addition to synthesizing RNA, RNAPII coordinates—through a variety of ...
Evaluating Measurement Error in Mass Spectrometry-Based Proteomics
(2020-01-22)
Over the last few decades, liquid chromatography with tandem mass spectrometry (LC-MS/MS) has become a pillar in the field of proteomics. As the popularity of and access to LC-MS/MS techniques grows, a concerted effort has ...
Investigating the Role of ZBTB33 Loss in Clonal Hematopoiesis and Hematologic Malignancies
(2020-04-21)
Clonal hematopoiesis describes a state in which an individual’s blood cells are disproportionately derived from one hematopoietic stem cell (HSC). Clonal somatic mutations in specific genes mutated in blood cancers can be ...
New Insights Into the Nature of the HIV-2 Reservoir
(2020-01-14)
Acquired immunodeficiency syndrome (AIDS) can be caused by two lentiviruses: HIV-1, which is responsible for the global AIDS pandemic, and HIV-2, which is endemic in west Africa. In Chapter 1, we show how the two viruses ...
Capture and Molecular Control of CD1a-Autoreactive T Cells in Human Skin
(2020-05-13)
Functional studies of T cell response have revealed the existence of CD1a autoreactive T cells in human skin, and CD1a tetramers might directly enumerate T cells (TCRs) and dissect the molecular basis for activation. We ...
Next-Generation Sequencing Techniques to Study HIV-1 Transcription and RNA Structure
(2020-05-14)
HIV-1 remains a global health challenge. New sequencing techniques and bioinformatic approaches are being developed to study key aspects of HIV-1 biology. I leveraged and developed innovative deep-sequencing approaches to ...
Prevention of Relapses in Mice With Ongoing EAE via Combined Allogeneic Bone Marrow and Neural Stem Cell Transplantation
(2020-01-21)
Multilineage mixed hematopoietic chimerism induces transplantation tolerance to allogeneic solid organ transplants in both animal models and humans. Yet we still have an imperfect understanding of the underlying mechanism ...
Encoding of 3D Head Movement and Direction in Visual Cortex
(2020-05-13)
Animals sample the visual world by producing complex patterns of movements that serve to stabilize or shift gaze, sample the visual scene, or estimate distance using parallax cues. Despite the myriad of movements animals ...
Graduate Student
(2020-04-06)
Pseudomonas aeruginosa is an opportunistic pathogen of humans that is on the Center for Disease Control’s list of top drug resistant threats in the United States. In this gram-negative bacterium the alp system encodes a ...