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Development of Small Molecule Kinase Degraders as Chemical Biology Probes and Cancer Therapies
(2018-09-20)
Advances in chemical biology provide immense benefits to human health through the discovery of new medicines and new scientific tools to study disease. I have contributed to the advancement of this field by developing a ...
Evolution of Diversely Functionalized Nucleic Acid Polymers
(2018-04-19)
Darwinian evolution gave rise to biopolymers with a myriad of folded structures and functions, as well as all the diverse life forms on earth that are supported by those molecules. Amazingly, the essence of molecular ...
The Development of a Cell-Based Screen for Discovering Lipopolysaccharide Biogenesis Inhibitors
(2018-09-16)
Gram-negative bacteria are more difficult to kill than Gram-positive bacteria due to the presence of an outer membrane that prevents many antibiotics from reaching their cellular targets. The outer membrane is an asymmetric ...