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Targeting FGFR to Overcome EMT-Related Resistance to EGFR Inhibition in EGFR-Mutated Non-Small Cell Lung Cancer
(2018-01-19)
Acquired drug resistance to tyrosine kinase inhibitor (TKI) targeted therapies remains a major clinical challenge. In EGFR mutant non-small cell lung cancer (NSCLC), therapeutic failure of EGFR TKIs can result from both ...
Glycomic regulation of human B cells
(2018-09-16)
All leukocytes are coated with a dense layer of carbohydrates called the glycocalyx. Initially believed to serve largely biophysical roles, the glycocalyx is increasingly recognized as a gatekeeper of leukocyte interactions ...
Directed evolution of Cas9 for mammalian genome editing
(2018-05-14)
The ability to manipulate the genome has been a longstanding goal since the discovery of the central dogma of molecular biology. Such a technology would not only allow us to correct deleterious mutations for human therapeutics ...
Investigating the Role of Heterogeneity in Breast Cancer and Experimental Design
(2018-08-31)
Breast cancer is predicted to be the most frequent newly diagnosed cancer and second leading cause of cancer-associated death among women in the United States in 2018. Intratumoral heterogeneity plays an important role in ...
Single-Cell Sequencing and in Vivo Analysis of the Biliary Epithelium Reveal a Dynamic and Essential Role for Yap
(2018-05-13)
The liver, which serves as the main filtration system for the body, is composed of a variety of cell types. Biliary epithelial cells (BECs), an essential cell type within the liver, serve as the main structural component ...