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Formation of a Termination-Resistant RNA Polymerase Complex: Studies on the Phage 82 Q Protein
(2015-07-22)
Due to their early discovery, relative simplicity, and well-defined function, the Q antiterminator proteins of bacteriophage lambda and related lambdoid phages serve as a model for understanding how the elongation and ...
Allosteric Integrase Inhibitors Reveal a Role for Integrase During HIV-1 Maturation
(2015-09-20)
Integration of the DNA copy of the HIV-1 genome is an essential step for virus replication and is mediated by a homotetrameric complex of the viral protein integrase (IN) in association with the ends of linear viral DNA ...
Interplay of Dengue Virus and the Human Immune Response
(2015-05-07)
RIG-I is a key cytosolic sensor of many RNA viruses, including dengue virus (DV), the most significant arboviral pathogen. Upon viral RNA binding, RIG-I signals via the adaptor protein MAVS, located at mitochondria, to ...
Discovery of a Small Molecule That Inhibits D-Alanylation of Teichoic Acids in Staphylococcus Aureus
(2015-05-12)
The Staphylococcus aureus cell envelope is a large, complex structure essential for cell shape and protection from the environment. It consists of membrane lipids, glycan polymers, and proteins, many of which have not been ...
Functional and Genomic Analyses of Klebsiella Pneumoniae Population Dynamics in the Gastrointestinal Tract
(2015-12-17)
The gastrointestinal tract is home to trillions of bacteria that interact with each other and with the host’s mucosal immune system. Obligate and facultative anaerobes thrive in the small and large intestine. While many ...
Coordinate control of virulence gene expression in Francisella tularensis
(2015-05-19)
Francisella tularensis is a Gram-negative, intracellular pathogen and the causative agent of tularemia. Due to its low infectious dose, ability to cause potentially fatal disease, and ability to be easily aerosolized, ...
A novel sigma factor antagonist that binds to RNA polymerase
(2015-05-18)
Sigma (σ) factors direct programs of gene expression by binding to and determining the promoter recognition specificity of RNA polymerase (RNAP). Genes transcribed under the control of alternative σs allow cells to respond ...
A sigma factor and anti-sigma factor that control swarming motility and biofilm formation in Pseudomonas aeruginosa
(2015-05-20)
Pseudomonas aeruginosa is an environmental bacterium and opportunistic human pathogen of major clinical significance. It is the principal cause of morbidity and mortality in patients with cystic fibrosis (CF) and a leading ...
TRIM22 IS A NOVEL RESTRICTION FACTOR OF HERPESVIRUSES
(2015-05-13)
The host response to the family of nuclear replicating DNA viruses or the herpesviruses includes the intrinsic, innate and adaptive arms of the immune system. Intrinsic resistance is a constitutively active line of defense ...
The Contribution of Cervicovaginal Microbiota and Hormonal Contraceptives to Genital Inflammation and HIV Acquisition Risk
(2015-05-17)
The HIV epidemic persists in many parts of the world, with the majority of new infections occurring through the female genital tract (FGT). The permissiveness of the genital mucosa to HIV is modulated by the integrity of ...