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Spatial Organizing Principles of Cytokinesis Signaling
(2015-09-23)
Cytokinesis is the final step of cell division, in which the cytoplasm of one cell is physically divided into two. Animal cells integrate multiple positional cues from the mitotic spindle to decide where to position their ...
Size Control and Uniformity in Animal Cells
(2015-04-08)
The homogeneity in cell size observed in many normal proliferating tissues, and the contrasting size disparities characteristic of several cancers, suggest that control mechanisms coordinate growth and cell cycle progression, ...
Large-Scale Analysis of Microtubule Pharmacology via Phosphoproteomics and High-Content Imaging
(2018-08-17)
The dynamic instability of microtubules is a critical phenomenon that regulates several biological processes. Chemical perturbation of microtubules disrupts these processes and is known to stimulate phosphorylation of ...
The Study of NSD2 Biochemical and Biological Activity Through Small-Molecule Profiling of Cell Lines
(2017-01-18)
Histone methyltransferase NSD2 (WHSC1/MMSET) is correlated with several cancers, but promising NSD2 inhibitors are yet to be developed for the clinic, alternative strategies should be studied parallel to probe development ...