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Resistance to Targeted Therapy in Sonic Hedgehog Subgroup Medulloblastoma: Mechanisms and Treatment Strategies
(2016-05-17)
Aberrant activation of the Sonic Hedgehog (Shh) signaling network is implicated in many human cancers, including the most common cancer, basal cell carcinoma (BCC) and the brain tumor medulloblastoma. Suppressing Shh ...
Neurotoxic Mechanisms of the Chemotherapeutic Paclitaxel
(2016-05-04)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of multiple chemotherapeutic agents for which there are currently no prevention strategies. The widely used chemotherapeutic paclitaxel ...
Organization of Postsynaptic Assembly by Filamin at the Drosophila Neuromuscular Junction
(2016-05-16)
Proper postsynaptic assembly is a fundamental requirement for circuit function, yet our understanding of its molecular mechanism is incomplete. The Drosophila neuromuscular junction is a powerful system for genetically ...
Genetic control of dendrite morphogenesis in C. elegans
(2016-05-17)
The shapes and attachments of cells determine the machinery of organs; for example, the shapes and attachments of neurons and glia establish the wiring of the brain. To understand how neuronal dendrites obtain their ...
Regulation of Neuronal Dendrite Development and Migration by the Atypical Cadherin Fat3
(2015-05-15)
Neuronal shape and position are critical to the formation and function of neuronal circuits. Although neurons develop axons and dendrites cell-autonomously in vitro, how extracellular cues in vivo direct neurite specification ...
In Vitro Studies of Amyotrophic Lateral Sclerosis Using Human Pluripotent Stem Cell-Derived Motor Neurons
(2015-05-14)
Among the disciplines of medicine, the study of neurological disorders such as amyotrophic lateral sclerosis (ALS) is particularly challenging. In ALS, both cortical and spinal motor neurons progressively degenerate, leading ...
Regulation of Transcytosis Underlies Blood-Brain Barrier Permeability
(2018-01-08)
The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is essential for proper neural function. A single layer of continuous endothelial cells lining the walls of central nervous system (CNS) ...
Mechanisms of Scale Invariance in Embryonic Patterning Systems
(2018-05-10)
Embryos pattern themselves with remarkable consistency and readily adjust their patterning programs to drastic changes in embryo size. This robustness of pattern formation, termed scale invariance, requires cells to determine ...