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Control of HIV-1C Replication Both in Vivo and in Vitro
(2015-05-18)
In this study, we established an HIV latency model using pluripotent stem cells in vitro. We found that a HIV accessory protein nef is responsible for full-length HIV silencing in human pluripotent stem cells. This effect ...
Spatiotemporal Control of Mycobacterium Tuberculosis Cell Wall Biogenesis by the Peptidoglycan Synthase PonA1
(2015-05-04)
Mycobacterium tuberculosis causes one of the most pernicious infectious diseases of humankind – tuberculosis, which is still a global problem in the 21st century. Drug-resistant M. tuberculosis infections are on the rise, ...
From Neural Stem Cells to Children: Secreted Phosphoprotein 1 in Lead Neurotoxicity
(2015-05-14)
Lead (Pb) exposure in the earliest stages of neurodevelopment leads to lasting deficits in cognitive function and behavior. Neural stem cells (NSCs) are multipotent stem cells and the first cells of the central nervous ...
Sialic acid variation as a determinant of Plasmodium invasion of erythrocytes in malaria infection
(2015-05-18)
Sialic acids are acidic sugars that terminate glycan chains on proteins or lipids on vertebrate cell surfaces. They vary greatly in structure, presentation and amount, all of which are important physiologically, but can ...
A Tale of Brothers, Sisters, Aunts and Uncles: Using Genomics and Modeling to Uncover the Nature of P. Falciparum Polygenomic Infections and Cotransmission
(2018-01-17)
A curious feature of malaria epidemiology is the presence of polygenomic (multiple strain) infections in natural parasite populations. Polygenomic infections are an important aspect of malaria transmission and a necessary ...