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Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer 

Subedee, Ashim (2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast tumors are classified based on the ...
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Genome-Wide RNAi Screens for Novel Regulators of Acute Myeloid Leukemia 

Li, Hubo (2015-01-15)
Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular mechanisms. Recent advent of genomic technologies, such as copy number profiling, whole genome sequencing, and gene expression profiling has ...
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Mechanisms of Stem Cell Maintenance and Cell Differentiation in the Intestinal Epithelium 

San Roman, Adrianna Katrina (2015-01-23)
Constant regeneration of the intestinal epithelium, a dynamic tissue with vital digestive and barrier functions, depends on proliferation of resident stem cells and their differentiation into mature cell types. This ...
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Investigating the Roles of IRF6 in Epithelial Maturation, Craniofacial Development, and Orofacial Cleft Pathogenesis 

Li, Edward Bing Hang (2018-04-10)
Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...
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The Effect of Development and Ecology on the Evolution of Ovary Size in Drosophila 

Sarikaya, Didem Pelin (2015-05-20)
How the size of an organ is established and altered during evolution is poorly understood. The ovary of fruit flies of the genus Drosophila serves as an interesting model for understanding organ size evolution, as the ...
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Oligopaints: Highly Programmable Oligonucleotide Probes for Visualizing Genomes in Situ 

Beliveau, Brian J. (2015-01-29)
Fluorescence in situ hybridization (FISH) is a powerful assay that can visualize the position of DNA and RNA molecules in individual cells. Here, I describe the development of a method that utilizes complex oligonucleotide ...
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The Molecular Determinants of Cranial Skeletal Development and Evolution 

Namkoong, Bumjin (2015-10-01)
The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ...
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Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation 

Peters, Derek Tilghman (2016-03-30)
A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...
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Homology and Heterology Effects in Drosophila: Cohesin and Condensin as Chromosome Choreographers 

Senaratne, Tharanga Niroshini (2016-05-02)
The organization of interphase nuclei has numerous consequences for gene expression and genome stability in eukaryotes. Here, we present studies of chromosome organization in Drosophila melanogaster over the course of the ...
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A Field Guide to The Limb Progenitor 

Rodrigues, Alan (2016-05-16)
The primary goal of this thesis was to characterize the embryonic limb progenitor, a cell type that populates the early limb bud during the onset of limb morphogenesis. Two features of the limb progenitor were explored 1) ...
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  • Biology, Cell$:$ (28)
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Except where otherwise noted, this work is subject to a Creative Commons Attribution 4.0 International License, which allows anyone to share and adapt our material as long as proper attribution is given. For details and exceptions, see the Harvard Library Copyright Policy ©2022 Presidents and Fellows of Harvard College.

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