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Mycobacterial Metabolic Syndrome: Triglyceride Accumulation Decreases Growth Rate and Virulence of Mycobacterium Tuberculosis
(2015-01-23)
Mycobacterium tuberculosis (Mtb) mutants lacking the operon Rv1411c-1410c encoding a lipoprotein, Rv1411c (LprG) and a putative transporter, Rv1410c (Rv1410) are dramatically attenuated for growth in mice. Previous work ...
Mechanisms Controlling the Cell Envelope Remodeling Activities of the Escherichia Coli Cytokinetic Ring
(2016-05-13)
In Escherichia coli, cytokinesis requires the constriction of all the cell envelope layers: the inner membrane, the peptidoglycan (PG) cell wall and the outer membrane (OM). Such dramatic cell envelope remodeling requires ...
Mode and Fidelity of Bacterial Symbiont Transmission and Its Impact on Symbiont Genome Evolution
(2016-05-18)
Mutualistic symbioses have enabled the colonization of novel habitats and niches in a large array of eukaryotic and bacterial taxa. Reliable mechanisms of symbiont transmission between host generations are necessary to ...
The Genetics of Life History Traits in the Fungus Neurospora crassa
(2016-05-13)
The study of life histories is fundamental to understanding why some organisms live for a very short time while others live for a long time, why some produce thousands of offspring while others produce one, or why some ...
Genome evolution in structured systems
(2016-05-14)
The evolution of a genome is shaped by spatial interactions at multiple scales. At the angstrom level, structural constraints on both RNA molecules and proteins contribute to the evolution of a gene sequence. Such optimized ...
Envelope biogenesis and spore formation in Bacillus subtilis
(2016-05-02)
The bacterial cell wall exoskeleton (or peptidoglycan) protects cells from osmotic lysis, specifies their shape, and its biosynthetic pathway is a widely-exploited antibiotic target. My thesis research focused on defining ...
New Genomics Tools and Strategies for Studying Antibiotics and Antibiotic-Resistance in Staphylococcus Aureus
(2016-05-18)
Staphylococcus aureus is a gram positive coccoid pathogen that causes intractable infections in hospitals and communities around the world, and tens of thousands of people die of these infections every year. In order to ...
Identifying targets for potentiators in S. aureus using chemical genetic approaches
(2016-09-29)
Staphylococcus aureus is a highly feared Gram-positive pathogen. The rise in antibiotic resistance has made S. aureus infections intractable. To find new ways to treat S. aureus infections, it is important to understand ...
A genetic dissection of the interactions between the CbtA toxin of Escherichia coli and the bacterial cytoskeleton
(2016-09-15)
Prokaryotic chromosomal toxin-antitoxin (TA) systems, consisting of a stable toxin and a labile, cotranscribed antitoxin, have been shown to target a number of essential processes in bacteria. The Escherichia coli genome ...
A sigma factor and anti-sigma factor that control swarming motility and biofilm formation in Pseudomonas aeruginosa
(2015-05-20)
Pseudomonas aeruginosa is an environmental bacterium and opportunistic human pathogen of major clinical significance. It is the principal cause of morbidity and mortality in patients with cystic fibrosis (CF) and a leading ...