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Plasmodium's Crossroads: Deciphering the Molecular Pathway That Leads to Malaria Transmission
(2015-05-13)
Plasmodium falciparum is the causative agent of the most severe form of malaria. Transmission from humans to mosquito vectors is an essential step in this eukaryotic parasite‘s life cycle and in the spread of malaria ...
Advances in Phage-Assisted Continuous Evolution and Application to Overcoming Bioinsecticide Resistance
(2016-05-20)
The Bacillus thuringiensis δ-endotoxins (Bt toxins) are widely used insecticidal proteins in engineered crops that provide agricultural, economic, and environmental benefits, constituting a substantial and increasingly ...
New Genomics Tools and Strategies for Studying Antibiotics and Antibiotic-Resistance in Staphylococcus Aureus
(2016-05-18)
Staphylococcus aureus is a gram positive coccoid pathogen that causes intractable infections in hospitals and communities around the world, and tens of thousands of people die of these infections every year. In order to ...
Drugs That Thwart Antibiotic Resistance
(2015-05-20)
Antibiotics are often credited with being one of the major forces behind the expansion of human life expectancy in the past 60 years. Yet at the root of this advancement lies its potential undoing: using antibiotics promotes ...
Uncovering Bacterial Metabolites Involved in Eukaryotic Development
(2016-09-09)
Microorganisms are ubiquitous. They crowd the soils, the oceans, even deserts and glaciers, and they make up the microbiota that live in and on the bodies of animals. Crammed into their environment with many other competing ...
Biophysical Studies of the Lpt Pathway
(2017-07-06)
The outer membrane (OM) of Gram-negative bacteria is impermeable to many antibiotics because its outer leaflet is composed entirely of lipopolysaccharide (LPS), a large glycolipid with an extracellular saccharide that is ...
Phage Assisted Evolutions for Engineering Biosynthetic Pathways
(2018-05-14)
Phage Assisted Continuous Evolution (PACE) and its derivative techniques are powerful tools for evolving improved and altered enzymatic activities. Prior to this work, no one had demonstrated the applicability of these ...
Discovery and Characterization of an Antimicrobial Toxin of the Gut Symbiont Bacteroides fragilis
(2018-08-17)
The gut microbiota represents one of most densely populated ecosystems on earth. The trillions of bacteria that populate the gastrointestinal tract carry out essential tasks for the host, such as harvesting energy from ...