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A Platform for the Discovery of New Macrolide Antibiotics
The macrolide class of antibiotics has been widely used to treat bacterial infections for over 65 years. To date, all practical routes to clinically used macrolide antibiotics have relied on the chemical modification of ...
Identifying targets for potentiators in S. aureus using chemical genetic approaches
Staphylococcus aureus is a highly feared Gram-positive pathogen. The rise in antibiotic resistance has made S. aureus infections intractable. To find new ways to treat S. aureus infections, it is important to understand ...
The Development of a Cell-Based Screen for Discovering Lipopolysaccharide Biogenesis Inhibitors
Gram-negative bacteria are more difficult to kill than Gram-positive bacteria due to the presence of an outer membrane that prevents many antibiotics from reaching their cellular targets. The outer membrane is an asymmetric ...
Investigations of the Biosynthesis and Structure of Colibactin, a Cytotoxin Made by Human-Associated Escherichia Coli
Humans exist in symbiosis with trillions of bacteria that are collectively referred to as the human microbiota. While commensal microbes are essential for health, some resident microbes can promote disease. Certain strains ...