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Genome evolution in structured systems
The evolution of a genome is shaped by spatial interactions at multiple scales. At the angstrom level, structural constraints on both RNA molecules and proteins contribute to the evolution of a gene sequence. Such optimized ...
Disentangling the Coevolutionary Histories of Animal Gut Microbiomes
Animals associate with microbes in complex interactions with profound fitness consequences. These interactions play an enormous role in the evolution of both partners, and recent advances in sequencing technology have ...
Genetic Engineering Toward a 57-Codon Genome
Scientific progress in fundamental biology has drastically transformed our ability to engineer biological systems, with diverse applications in medicine and industry, from insulin and artemisin production in prokaryotes ...
Free Actin and Effects on Lung Macrophage Bacterial Defenses
Actin release into the circulation and extracellular space, with subsequent removal by the actin scavenging protein plasma gelsolin (pGSN), has long been reported in injury and infection. Our laboratory’s recent finding ...
The Role of MreB in Producing Rod-Shaped Bacterial Cells
MreB, an actin homolog, is known to form short, membrane-associated filaments that move circumferentially in rod-shaped bacteria, in association with cell wall-synthesizing enzymes. Despite being essential for rod shape, ...