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The Contribution of Cervicovaginal Microbiota and Hormonal Contraceptives to Genital Inflammation and HIV Acquisition Risk
The HIV epidemic persists in many parts of the world, with the majority of new infections occurring through the female genital tract (FGT). The permissiveness of the genital mucosa to HIV is modulated by the integrity of ...
TRIM22 IS A NOVEL RESTRICTION FACTOR OF HERPESVIRUSES
The host response to the family of nuclear replicating DNA viruses or the herpesviruses includes the intrinsic, innate and adaptive arms of the immune system. Intrinsic resistance is a constitutively active line of defense ...
Enterococcus infection of Caenorhabditis elegans as a model of innate immunity
The vast majority of metazoan species are invertebrates, which lack an adaptive immune system for defense against microbes. Instead, their innate immune system is sufficient for defense against pathogenic organisms, which ...
Markov-Based Model of Cervicovaginal Bacterial Dynamics Predicts Community Equilibrium States in Young South African Women
Commensal cervicovaginal bacteria modulate female genital tract (FGT) inflammation and HIV acquisition risk. High diversity communities with low Lactobacillus abundance are associated with more activated cervical HIV target ...
Interplay of Dengue Virus and the Human Immune Response
RIG-I is a key cytosolic sensor of many RNA viruses, including dengue virus (DV), the most significant arboviral pathogen. Upon viral RNA binding, RIG-I signals via the adaptor protein MAVS, located at mitochondria, to ...