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Structural and Functional Studies Into Nramp Divalent Metal Transporter Mechanisms
(2015-07-10)
The Nramp (natural resistance associated macrophage protein) family of transition metal ion transporters is an important class of secondary active transporters involved in metal homeostasis used by all branches of life. ...
The Molecular Determinants of Cranial Skeletal Development and Evolution
(2015-10-01)
The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ...
Evolving Models of Ovarian Cancer: Defining the Role of PAX8 in Fallopian Tube Tumorigenesis
(2015-08-07)
Ovarian cancer is the most deadly gynecological malignancy in the US. Once thought to be a single disease arising from the ovarian surface epithelium, we now understand that it is in fact a heterogenous disease with origins ...
A Structural and Functional Investigation of Germ Plasm Organization Mediated by D. Melanogaster Oskar Protein
(2015-09-25)
Germ cells are the unique source of gametes for multicellular organisms and are specified through different mechanisms. One such specification mechanism is inheritance-mediated, in which the molecular factors necessary and ...
Transcriptional Control of Maternal-Fetal Immune Tolerance
(2016-05-18)
Human leukocyte antigens (HLA) are important determinants of self-nonself immune recognition. HLA-G, uniquely expressed in the placenta, is believed to be key to fetus-induced immune tolerance during pregnancy. The ...
The Discovery and Characterization of the lncRNA Firre
(2015-05-08)
RNAs, including long noncoding RNAs (lncRNA), are known to be abundant and important structural components of the nuclear infrastructure. Yet, the identities, functional roles, and localization dynamics of lncRNAs that ...
Classical Conditioning Alters Short Noncoding RNA Expression in Drosophila
(2015-05-14)
MicroRNAs (miRNAs) and other classes of short non-coding RNAs regulate essential processes in the development and function of the nervous system. Regulation of miRNAs by neural activity has also been reported. Recently, ...
Discovery and In Vivo Characterization of Long Noncoding RNAs
(2016-05-17)
The noncoding genome, or the portion of the genome that does not encode for proteins, encompasses >95% of the human genome. It has been found that the majority of disease-associated genetic variants identified by genome-wide ...
Balancing transcriptional activity in Drosophila through protein-protein interactions on chromatin
(2016-05-09)
Chromatin plays a vital role in the implementation of gene expression programs. Several disparate groups of regulatory proteins alter chromatin state through post-translational modification of histone proteins, nucleosome ...
Post-Transcriptional Control of Multicellularity in Bacillus subtilis
(2016-05-13)
Bacteria are capable of sensing changes in their environment and responding to those changes by altering patterns of gene expression. There are many mechanisms by which bacteria can sense internal and external signals. The ...