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Comprehensive Approaches to Identifying the Targets of Natural and Synthetic Antibodies Using Microarray DNA Synthesis and High-Throughput Sequencing
The incredible flexibility and specificity of the humoral immune response is dependent on the highly diverse repertoire of naïve and affinity-matured antibodies. Utilizing and understanding the power of this response ...
Single Molecule FRET Studies of Reverse Transcription and Chromatin Remodeling
The measurement of Förster resonance energy transfer (FRET) at the single-molecule level provides a powerful method for monitoring the structural dynamics of biomolecular systems in real time. These single-molecule FRET ...
Machine-guided design and evolution of biological systems: from the protein to the genome scale
Evolution has shown that mutation and selection over billions of years can produce complex molecules and organisms that thrive in a diverse range of environments. As biological engineers, we would like to systematize the ...