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Lessons From Cyclosporine A: Structural Determinants of Conformation-Switching and Passive Membrane Penetration
(2015-10-15)
The structural complexity of ‘beyond-rule-of-5’ compounds, such as peptide macrocycles, may facilitate access to additional biological target space beyond the enzymatic active site. Naturally occurring cyclic peptides, in ...
Plasmodium's Crossroads: Deciphering the Molecular Pathway That Leads to Malaria Transmission
(2015-05-13)
Plasmodium falciparum is the causative agent of the most severe form of malaria. Transmission from humans to mosquito vectors is an essential step in this eukaryotic parasite‘s life cycle and in the spread of malaria ...
Advances in Phage-Assisted Continuous Evolution and Application to Overcoming Bioinsecticide Resistance
(2016-05-20)
The Bacillus thuringiensis δ-endotoxins (Bt toxins) are widely used insecticidal proteins in engineered crops that provide agricultural, economic, and environmental benefits, constituting a substantial and increasingly ...
Assembly and Regulation of the Inflammasome Governed by a Unified Polymerization Mechanism
(2016-05-13)
The innate immune system employs a diverse set of pattern recognition receptors to detect intrinsic and extrinsic danger signals for host protection. Inflammasomes represent an important class of receptors that elicit ...
Directed Evolution and Engineering of CRISPR-Associated Nucleases
(2016-09-12)
CRISPR-Cas systems provide prokaryotes with a remarkable mechanism for adaptive immunity, and recent efforts to understand these systems have provided tremendous insight into the complex nature of these systems. Despite ...
The Study of NSD2 Biochemical and Biological Activity Through Small-Molecule Profiling of Cell Lines
(2017-01-18)
Histone methyltransferase NSD2 (WHSC1/MMSET) is correlated with several cancers, but promising NSD2 inhibitors are yet to be developed for the clinic, alternative strategies should be studied parallel to probe development ...