Now showing items 1-4 of 4
Development of New Tools for Single-Molecule Force Spectroscopy & The Application of these Tools to Mapping the Role of Force Directionality in the Actin Mechanome
Actin filaments serve as a hub of focal adhesion-based mechanotransduction network in a wide variety of cell types. In this role filaments and networks of filaments are exposed to forces in a range of directions and ...
Exploring Biomolecular Interactions Through Single-Molecule Force Spectroscopy and Computational Simulation
Molecular interactions between cellular components such as proteins and nucleic acids govern the fundamental processes of living systems. Technological advancements in the past decade have allowed the characterization of ...
High-Throughput Genetic Analysis of Single Cells Using Microfluidically Generated Hydrogels
Typical metagenomic datasets characterize populations as a whole by sequencing all the DNA fragments present in a sample, and are therefore unable to identify different genes as having originated from the same cell or ...
Engineering Molecules, Mineralization and Magnetism in Biology by Directed Evolution and Computation
The intersection of synthetic biology with physics and computer science generates rich opportunities for both advancing our understanding of biological entities and systems as well as engineering biology to address a variety ...