Search
Now showing items 1-10 of 42
Contextual Modulation of Early Visual Processing and the Role of Cortico-Cortical Feedback
(2016-05-14)
How does the brain form a useful representation of its external environment from the astoundingly complex patterns of sensory signals it receives? This question has motivated the field of systems neuroscience for decades. ...
Emergence of Reward Coding in the Olfactory System
(2016-05-17)
Identifying dangerous or rewarding elements in an animal’s surroundings is an important – if not primary – function of sensory systems. This holds particularly true for the mouse olfactory system since odors convey crucial ...
The Brain Has an Innate Immune Response That Can Limit Virus Spread
(2016-05-17)
The brain has a tightly regulated environment that protects non-regenerating post-mitotic neurons and limits inflammation, which led to its description as a site of ‘immune privilege’. For example, viral and bacterial ...
The Role of the Basal Ganglia in Executing and Learning Complex Motor Sequences
(2016-05-17)
We learn and perform precise motor sequences to interact with the environment. This ability underlies much of what we do, from playing musical instruments and using new tools to producing fluent speech. Understanding the ...
Neural Circuit Mechanisms Underlying Skill Learning, Adaptation, and Maintenance
(2016-05-18)
Part I
Mastering a motor skill, such as a playing the guitar, requires precisely controlling both spatial and temporal aspects of motor output – that is, what movements to perform when. While it is generally assumed that ...
Resistance to Targeted Therapy in Sonic Hedgehog Subgroup Medulloblastoma: Mechanisms and Treatment Strategies
(2016-05-17)
Aberrant activation of the Sonic Hedgehog (Shh) signaling network is implicated in many human cancers, including the most common cancer, basal cell carcinoma (BCC) and the brain tumor medulloblastoma. Suppressing Shh ...
Coding of Internal Senses: Vagal Gut-to-Brain Circuits
(2016-05-17)
Our ability to detect features of environments in and around us is fundamental. Organisms have developed highly specialized systems to allow for transduction of a broad variety of stimuli to convey sensory information to ...
A Role for Corticothalamic Feedback in Developmental Refinement at the Retinogeniculate Synapse.
(2016-05-16)
The primary image-forming pathway in the mammalian visual system relays information from photoreceptors in the retina through the dorsolateral geniculate nucleus (dLGN) in the thalamus to primary visual cortex (V1). In ...
Neurotoxic Mechanisms of the Chemotherapeutic Paclitaxel
(2016-05-04)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of multiple chemotherapeutic agents for which there are currently no prevention strategies. The widely used chemotherapeutic paclitaxel ...
Biochemical and Genomic Analysis of MeCP2 and Brain-Enriched DNA Methylation
(2016-04-14)
Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder with features of autism. MECP2 encodes a methyl-CpG-binding protein that has been proposed to function as a transcriptional repressor, ...