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Linking Metabolic Rates with the Diversity and Functional Capacity of Endolithic Microbial Communities within Hydrothermal Vent Structures
(2013-10-18)
At hydrothermal vents, thermal and chemical gradients generated by the mixing of hydrothermal fluids with seawater provide diverse niches for prokaryotic communities. To date, our knowledge of environmental factors that ...
Structure and development of Rafflesiaceae
(2013-10-17)
Rafflesiaceae produce the largest flowers among all flowering plants, measuring up to a meter in diameter and weighting 7 kg, and have been a source of amazement since their discovery about two centuries ago. In addition ...
Molecular Dissection of Neural Circuits Underlying Parental Behavior in Mice
(2013-10-18)
Mice display robust and stereotyped behaviors towards pups: virgin males typically attack pups, while virgin females and sexually experienced males display parental care. I show here that virgin males that are genetically ...
Phosphatome RNAi Screen Identifies Eya1 as a Positive Regulator of Hedgehog Signal Transduction
(2013-10-18)
The Hedgehog (Hh) signaling pathway is vital for vertebrate embryogenesis and aberrant activation of the pathway can cause tumorigenesis in humans. In this study, we used a phosphatome RNAi screen for regulators of Hh ...
Evolution of Bivalvia: Multi-level phylogenetic and phylogenomic reconstructions within Bivalvia (Mollusca) with emphasis on resolving familial relationships within Archiheterodonta (Bivalvia: Heterodonta).
(2013-10-15)
With an estimated 8,000-20,000 species, bivalves represent the second largest living class of molluscs (Bieler et al. 2013). Revived interest in molluscan phylogeny has resulted in a torrent of molecular sequence data from ...
Mechanisms Governing Mesothelial Clearance by Ovarian Cancer Spheroids
(2013-10-08)
Metastatic dissemination of ovarian tumors involves the invasion of multi-cellular tumor cell clusters into the mesothelial cell lining of organs in the peritoneal cavity. We developed an in vitro assay that models this ...
Functional Contribution of PDGFRbeta+ Cells in Angiogenesis and Metastatic Breast Cancer
(2013-10-18)
Tumor stroma is known to affect tumor growth and metastasis. Inhibiting PDGF signaling, with the goal of depleting PDGFRβ+ stromal cells, is a putative therapeutic approach in this context. PDGFRβ is widely ...
Probing Protein Interactions with Stapled Peptides: Myc Family and Insulin Receptor
(2013-10-15)
One of the most exciting frontiers of expanding pharmacopeia to combat currently untreatable diseases is achieving specifically and potently disruption of unwanted protein-protein interactions where traditional small ...
Smoothened regulation in the Hedgehog signaling pathway
(2013-10-18)
Hedgehog signaling is a pathway essential in embryonic development, adult stem cell maintenance, and is implicated in the formation and progression of cancer. Signaling in this pathway is triggered when the secreted protein ...
Physiological and Pharmacological Regulation of the STAT3 Pathway in Cancer
(2013-10-18)
STAT3 is a critical oncogenic transcription factor, but how it becomes aberrantly activated in cancer is unclear. We have discovered a new pathway whose loss is associated with persistent STAT3 activation in human cancer. ...