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Investigating Cytoskeletal Motor Mechanisms using DNA Nanotechnology
(2014-02-25)
The microtubule cytoskeleton plays a vital role in the spatial-temporal organization of subcellular cargo required to maintain homeostasis and direct cell division. Cytoplasmic dynein and kinesin are opposite-polarity, ...
CRISPR-Cas: Development and applications for mammalian genome editing
(2014-06-06)
The ability to introduce targeted modifications into genomes and engineer model organisms holds enormous promise for biomedical and technological applications, and has driven the development of tools such as zinc finger ...
Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas
(2014-06-06)
With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted ...
Physiological and Pharmacological Regulation of the STAT3 Pathway in Cancer
(2013-10-18)
STAT3 is a critical oncogenic transcription factor, but how it becomes aberrantly activated in cancer is unclear. We have discovered a new pathway whose loss is associated with persistent STAT3 activation in human cancer. ...
Discovery and Characterization of Novel Bioactive Peptides and a Natural ERRalpha Ligand
(2013-10-17)
Metabolites and peptides have a central role in biology that is often overlooked. Despite the importance of metabolites in key protein-metabolite interactions (PMIs), the extent and identity of these interactions is not ...
Exploring Dengue Virus Entry through Small Molecule Inhibition and Mutagenesis of the Envelope Protein
(2013-03-15)
Over one-third of the world’s population is at risk for infection with dengue virus (DENV), a mosquito-borne virus that can cause a severe febrile disease. There are no specific treatments available for dengue infection, ...
Defining and Targeting Transcriptional Pathways in Leukemia Stem Cells
(2014-10-21)
Acute myeloid leukemia (AML) is a clonal neoplastic disorder organized as a cellular hierarchy, with the self-renewing leukemia stem cell (LSC) at the apex. Recurrent mutations in transcription factors (TF) and epigenetic ...
Oxidative Assembly of the Outer Membrane Lipopolysaccharide Translocon LptD/E and Progress towards Its X-Ray Crystal Structure
(2014-10-21)
Lipopolysaccharide (LPS) is the glycolipid that comprises the outer leaflet of the Gram-negative outer membrane (OM). Because it is essential in nearly all Gram-negative species, and because it is responsible for making ...
Regulatory consequences of variation in transcription factor-DNA binding
(2022-03-17)
Transcription factors bind to their target DNA sites in a sequence-specific manner, modulating gene expression, and playing important roles in development, body patterning, cellular differentiation, and stimuli response. ...
Structure, Function, and Engineering of Relaxin Hormones and Receptors
(2022-03-17)
The relaxin family peptide receptor 1 (RXFP1) and its agonist, relaxin-2, are of significant therapeutic interest in the areas of cardiovascular and fibrotic diseases. RXFP1 is a family A G protein-coupled receptor (GPCR), ...