Search
Now showing items 1-10 of 13
Mechanisms Governing Mesothelial Clearance by Ovarian Cancer Spheroids
(2013-10-08)
Metastatic dissemination of ovarian tumors involves the invasion of multi-cellular tumor cell clusters into the mesothelial cell lining of organs in the peritoneal cavity. We developed an in vitro assay that models this ...
Functional Contribution of PDGFRbeta+ Cells in Angiogenesis and Metastatic Breast Cancer
(2013-10-18)
Tumor stroma is known to affect tumor growth and metastasis. Inhibiting PDGF signaling, with the goal of depleting PDGFRβ+ stromal cells, is a putative therapeutic approach in this context. PDGFRβ is widely ...
Physiological and Pharmacological Regulation of the STAT3 Pathway in Cancer
(2013-10-18)
STAT3 is a critical oncogenic transcription factor, but how it becomes aberrantly activated in cancer is unclear. We have discovered a new pathway whose loss is associated with persistent STAT3 activation in human cancer. ...
Optically-Active Nanomaterials for Diagnostic and Therapeutic Applications in Ovarian Cancer
(2014-06-06)
The clinical management of cancer has principally relied upon surgery, radiation therapy, and chemotherapy for many decades. Despite recent advances in molecularly-targeted diagnostic and therapeutic agents, the long-term ...
Glucose Metabolism in Cancer-Associated Fibroblasts
(2013-08-28)
Under normal conditions, non-transformed cells rely on glycolysis followed by
oxidative phosphorylation to generate ATPs. When oxygen is scarce or when cells are
actively proliferating, cellular ATPs come mainly from ...
Development and Application of Lysate Microarray Technology for Quantitative Analysis of Human Disease
(2013-08-28)
Reductionist biology has yielded tremendous insight into the basis of biochemistry and genetic disease. However, the remarkable failure of reductionist biology to explain complex problems, especially cancer, has led to the ...
Genetic Determinants and Evolutionary Trajectories of Chronic Lymphocytic Leukemia
(2020-11-23)
Chronic lymphocytic leukemia (CLL), the most common adult B cell malignancy, is known to have a variable disease course and multiple modes of therapeutic resistance. Recent large-scale sequencing efforts have uncovered ...
Dysregulation of mSWI/SNF (BAF) Complexes in Human Malignancy
(2021-11-16)
Mammalian SWI/SNF (mSWI/SNF or BAF) complexes are multi-subunit, ATP-dependent, chromatin-remodeling protein complexes that increase the accessibility of DNA to transcriptional machinery. BAF complex perturbations are found ...
A Noncanonical Role of MCL-1 in Cell Cycle Progression
(2022-06-06)
Myeloid cell leukemia 1 (MCL-1) is an anti-apoptotic BCL-2 family protein implicated in the development, maintenance, and chemoresistance of human cancer. MCL-1 is one of the most frequently amplified genes across a broad ...
Transcriptional Constraint Of EWS/FLI Promotes Ewing Sarcoma
(2022-03-17)
Pediatric cancers are fundamentally epigenetic diseases of dysregulated development and harbor few mutations in genes involved in immediately druggable pathways. Recently, the hijacking of cell type-specific transcription ...