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Transcriptomic analyses of brain white matter in human neurodegenerative tauopathies
(2020-11-23)
Neurodegeneration is a debilitating process defining diseases such as Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Research on neurodegeneration has focused on neuronal tau protein accumulation, ...
The Plastic and Adaptive Evolutionary Potential of Nonstructural Carbohydrates in a Temperate Tree Species
(2020-09-28)
The ability to undergo plastic and evolutionary change in adaptive traits is key for plant survival under future climate change. Both processes require genetic variation in adaptive traits within populations. Thus, for my ...
On the evolution of sex and its consequences
(2020-09-25)
This dissertation is an empirical and theoretical examination of the evolution of sex, sex-determining mechanisms, and sexual selection. Chapter 1 surveys adult sex ratios across species and populations of Anolis lizards ...
Evolutionary dynamics of deletions removing regulatory features in the human noncoding genome
(2020-10-13)
Genomic deletions provide a powerful loss-of-function model in noncoding regions to assess the role of purifying selection on human noncoding genetic variation. Regulatory element function is characterized by non-uniform ...
Integrating Ancient and Modern DNA To Study Human History in South Asia and the Americas
(2020-09-10)
In the last two decades, advances in next-generation sequencing, genome-wide genotyping arrays, and methods to obtain DNA from ancient individuals have propelled the field of population genetics such that it is now an ...
Genetic Determinants and Evolutionary Trajectories of Chronic Lymphocytic Leukemia
(2020-11-23)
Chronic lymphocytic leukemia (CLL), the most common adult B cell malignancy, is known to have a variable disease course and multiple modes of therapeutic resistance. Recent large-scale sequencing efforts have uncovered ...
On localizing the effects CRISPR Gene-Drives and safeguarding our shared future
(2020-11-23)
Through advances in homing endonuclease engineering and the advent of the CRISPR class RNA-guided endonucleases, the construction, testing, and field deployment of gene drive technology have moved rapidly from theory into ...
Functional characterization of genetic variation with in silico predictions of cell-type-specific regulatory elements
(2020-09-10)
Genome-wide association studies (GWAS) have implicated thousands of complex trait-variant associations, an estimated 90% of which reside in the noncoding genome. While noncoding variants generally have poorly understood ...