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Neural Circuits at the Intersection of Feeling and Deciding
(2013-03-08)
Affect plays a central role in perception and action. We register how good or bad we feel about objects in our environment at the moment of perception. These associations can guide decisions between different courses of ...
Molecular Dissection of Neural Circuits Underlying Parental Behavior in Mice
(2013-10-18)
Mice display robust and stereotyped behaviors towards pups: virgin males typically attack pups, while virgin females and sexually experienced males display parental care. I show here that virgin males that are genetically ...
Interaction Proteomics of Autism Spectrum Disorder- and Intellectual Disability-Associated Proteins Identifies a Novel Hap1-Tsc1 Signaling Link that Controls Neuronal mTORC1 Signaling and Pyramidal Neuron Morphogenesis
(2013-10-18)
Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental disorders of cognition that remain incompletely understood. Here, using a computation-assisted interaction proteomics approach in neural ...
Single-Neuron Sequencing to Explore Somatic Genetic Variants in Normal and Pathological Human Brain Development
(2013-09-30)
The human brain is one of the most exquisite structures in nature, featuring extreme functional complexity and capacities that allow for advanced cognitive abilities. During the development of the human brain, neural ...
Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons
(2013-10-08)
Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program ...
Coupling the small GTPase Rab3 to the Synaptic Vesicle Cycle
(2013-10-08)
Coupling the small GTPase Rab3 to the Synaptic Vesicle Cycle
Initiating Complement-Dependent Synaptic Refinement: Mechanisms of Neuronal C1q Regulation
(2013-09-24)
Immune molecules, including complement proteins, C1q and C3, have emerged as critical mediators of synaptic refinement and plasticity. Complement proteins localize to synapses and refine the developing retinogeniculate ...
Characterization of human TRPA1 and TRPV1 channels in response to naturally occurring defensive compounds
(2013-10-08)
The transient receptor potential channels, ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1), are non-selective cation-permeable channels that have retained their function as chemical sensors since their first appearance in metazoan ...
The Rat Ventromedial Prefrontal Cortex in the Neural Circuitries of Depression and Sleep
(2013-09-26)
Major depressive disorder (MDD) is a debilitating disorder affecting hundreds of millions of people worldwide. The etiology of the disease is unknown, and how antidepressant medications reverse depression is unclear. ...
Single-cell Sequencing Studies of Somatic Mutation in the Human Brain
(2013-10-08)
A major unanswered question in neuroscience is whether there exists genomic variability between individual neurons of the brain, contributing to functional diversity or to an unexplained burden of neurologic disease. To ...