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Designing Scalable Biological Interfaces
(2014-06-06)
This thesis presents the analysis and design of biological interfacing technologies in light of a need for radical improvements in scalability. It focuses primarily on structural and functional neural data acquisition, but ...
Directed differentiation of mouse embryonic stem cells into neocortical output neurons
(2013-10-18)
During development of the neocortex, many diverse projection neuron subtypes are generated under regulation of cell-extrinsic and cell-intrinsic controls. One broad projection neuron class, corticofugal projection neurons ...
Internal Representations for the Generalization of Motor Memories
(2013-03-14)
Movement and memory are two of the most fundamental components of our existence. From the moment of birth, we rely on a variety of movements to interact with people and objects around us, and as we grow, we continuously ...
A Role for Focal Adhesions and Extracellular Matrix in Traumatic Axonal Injury
(2014-10-21)
Traumatic Brain Injury (TBI) is linked to a diverse range of diffuse pathological damage for which there is a severe lack of therapeutic options. A major limitation to drug development is the inability to identify causal ...
Multisensory Integration of Spatio-Temporal Information in Attention and Working Memory
(2021-01-08)
Real-world perception is fundamentally multifaceted and multisensory. It requires us to attend and remember temporal and spatial features of multiple objects in different sensory modalities, and to selectively integrate ...
Model of Human-Vehicle Closed Loop Control: Effects of Altered Gravity and Vestibular Sensory Precision
(2022-06-03)
The vestibular system provides the brain with information about head motion and orientation relative to gravity, which are important sensory cues for postural control and movement coordination. Due to noise in the nervous ...
Understanding How Environmental Dynamics and Uncertainty Affect Adaptive Changes in Motor Planning
(2022-03-18)
The elegance and vigor of movements that organisms repeatedly display belie the incredible challenge of controlling these movements. Remarkably, the motor system can achieve smooth and robust motor control undeterred by ...
Toward Therapeutic Control of Circadian Rhythms: Optimisation of Pharmaceutical Administration Models for Circadian Entrainment via Nonlinear Model Predictive Control
(2023-06-30)
The ability to shift circadian phase in vivo has the potential to offer substantial health benefits, and constructing an appropriate model — from therapeutic administration to phase response — will enable this possibility. ...