Two-photon laser scanning microscopy (2PLSM) allows fluorescence imaging in thick biological samples where absorption and scattering typically degrade resolution and signal collection of 1-photon imaging approaches. The ...

Cellular lipid membranes can – and often do – support a transmembrane electric field, serving as biological capacitors that maintain a voltage difference between their two sides. It isn't hard to see why these ...

This thesis presents the analysis and design of biological interfacing technologies in light of a need for radical improvements in scalability. It focuses primarily on structural and functional neural data acquisition, but ...

My work has focused on the development and application of fluorescent voltage-sensitive proteins based on microbial rhodopsins. These probes led to the discovery of electrical activity in the bacterium Escherichia coli, ...

Presynaptic terminals of neurons are optimized for neurotransmitter release, which is tightly controlled by presynaptic calcium. Here, we evaluate the role of calcium influx through voltage-gated calcium channels (VGCCs) ...

How do animals use their sensory neurons to perceive their chemical environment? How does sensory information get transformed by downstream circuits? And ultimately, how do animals generate behavior in response to chemical ...

Primary mechanosensors encode the detailed features of mechanical stimuli, with different neurons extracting different stimulus features. How this occurs is not fully understood. This is due partially to the difficulty of ...