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Single-Neuron Sequencing to Explore Somatic Genetic Variants in Normal and Pathological Human Brain Development
(2013-09-30)
The human brain is one of the most exquisite structures in nature, featuring extreme functional complexity and capacities that allow for advanced cognitive abilities. During the development of the human brain, neural ...
Single-cell Sequencing Studies of Somatic Mutation in the Human Brain
(2013-10-08)
A major unanswered question in neuroscience is whether there exists genomic variability between individual neurons of the brain, contributing to functional diversity or to an unexplained burden of neurologic disease. To ...
Genome-Wide Identification and Characterization of Stimulus-Responsive Enhancers in the Nervous System
(2013-08-21)
During development, intrinsic genetic programs give rise to distinct cellular lineages through the establishment of cell type specific chromatin states. These distinct chromatin states instruct gene expression primarily ...
DEVELOPMENT AND FUNCTIONS OF C-LOW-THRESHOLD MECHANORECEPTORS
(2013-10-08)
Somatosensory neurons are essential for detecting diverse environmental stimuli, thus critical for survival of mammals. In order to achieve sensory modality specificity, many somatosensory subtypes emerge with various ...
Building a Bigger Brain: Centriole Control of Cerebral Cortical Development
(2014-10-21)
Human genetics has identified essential roles for many centriole- and cilia-related proteins during human development. Mutations in centrosome-associated genes commonly cause microcephaly, or "small brain," and mutations ...
A specialized serotonergic neuron subtype transduces chemosensory signals and regulates breathing
(2014-06-06)
Serotonergic neurons modulate a wide range of behaviors and functions, from mood and aggression to vital autonomic processes like heart rate, respiratory dynamics, and body temperature. We hypothesize that this broad scope ...
Transcriptomic analyses of brain white matter in human neurodegenerative tauopathies
(2020-11-23)
Neurodegeneration is a debilitating process defining diseases such as Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Research on neurodegeneration has focused on neuronal tau protein accumulation, ...
Quantitative analysis of clonal architecture across the human cerebral cortex using somatic mutations
(2021-07-12)
The human cerebral cortex shows remarkable functional specialization into regions devoted to motor, sensory, or visual functions, and these functional areas correlate with dramatic differences in cellular composition, or ...
Development of bipolar interneuron subtypes within the retinal space-time continuum
(2022-01-18)
Development of the retina requires precise production of more than 100 neuronal subtypes.
How does such diversity emerge during development at the perfect time and place to create functional
circuitry? Recent molecular ...
Neurochemically distinct median raphe subsystems: unique hodology and presynaptic specializations
(2021-11-16)
From their somata residing in the brainstem, neurons expressing the master serotonergic regulator gene Pet1 (aka Fev) extend axonal projections to forebrain regions underlying such diverse functions as sleep, memory, ...