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Single-Neuron Sequencing to Explore Somatic Genetic Variants in Normal and Pathological Human Brain Development
(2013-09-30)
The human brain is one of the most exquisite structures in nature, featuring extreme functional complexity and capacities that allow for advanced cognitive abilities. During the development of the human brain, neural ...
Coupling the small GTPase Rab3 to the Synaptic Vesicle Cycle
(2013-10-08)
Coupling the small GTPase Rab3 to the Synaptic Vesicle Cycle
The X-linked Intellectual Disability Protein PHF6 Associates with the PAF1 Complex and Regulates Neuronal Migration in the Mammalian Brain
(2013-10-08)
Intellectual disability is a prevalent developmental disorder for which no effective treatments are available. Mutations of the X-linked protein PHF6 cause the Börjeson-Forssman-Lehmann syndrome (BFLS) that is characterized ...
Alternative Splicing Regulation in Programmed Cell Death and Neurological Disorders: A Systems Biology Approach
(2013-09-30)
Alternative splicing (AS) is a major source of biological diversity and a crucial determinant of cell fate and identity. Characterizing the role of AS regulatory networks in physiological and pathological processes remains ...
The Role of the Human Tau 3'-Untranslated Region in Regulating Tau Expression
(2013-10-18)
The microtubule-associated protein tau forms pathological neuronal filaments in Alzheimer's disease (AD) and other neurodegenerative disorders, known collectively as tauopathies. Previous studies in transgenic mouse models ...
Modeling sporadic Alzheimer's disease using induced pluripotent stem cells
(2014-10-22)
Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation ...
Functional and genomic analysis of MEF2 transcription factors in neural development
(2014-10-21)
Development of the central nervous system requires the precise coordination of intrinsic genetic programs to instruct cell fate, synaptic connectivity and function. The MEF2 family of transcription factors (TFs) plays many ...
Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network
(2021-07-12)
Behavioral experiences activate the Fos transcription factor in sparse populations of neurons that are critical for encoding and recalling specific events. However, there is limited understanding of the mechanisms by which ...
A Molecular Trigger for Sea Anemone Stinging
(2021-05-17)
Understanding the mechanisms by which cells detect, integrate, and respond to distinct sensory cues is of fundamental importance to biological systems. Cnidarians, such as jellyfish, hydroids, and sea anemones, use specialized ...
Molecular and cellular mechanisms underlying adult blood-brain barrier maintenance
(2022-01-20)
To ensure optimal neuronal function, the blood-brain barrier (BBB) maintains a homeostatic brain microenvironment free from harmful agents and delivers nutrients to the brain to support metabolic needs. Although the BBB ...