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Interpretable Machine Learning Methods with Applications in Genomics
(2020-08-10)
A primary goal in biology is understanding the relationship between genomic sequence and cell state or function. Pharmacogenomic experiments, for instance, measure how different genomic profiles correlate with cell survival ...
Off-Policy Evaluation of Reinforcement Learning in Healthcare
(2020-08-10)
Reinforcement learning is a method for learning optimal strategies for tasks which require making sequences of decisions. The ability to make decisions in a manner which balances short versus long term outcomes makes ...
Functional characterization of genetic variation with in silico predictions of cell-type-specific regulatory elements
(2020-09-10)
Genome-wide association studies (GWAS) have implicated thousands of complex trait-variant associations, an estimated 90% of which reside in the noncoding genome. While noncoding variants generally have poorly understood ...