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Designing Scalable Biological Interfaces
(2014-06-06)
This thesis presents the analysis and design of biological interfacing technologies in light of a need for radical improvements in scalability. It focuses primarily on structural and functional neural data acquisition, but ...
Control of Neurotransmitter Release Properties by Presynaptic Calcium
(2014-06-06)
Presynaptic terminals of neurons are optimized for neurotransmitter release, which is tightly controlled by presynaptic calcium. Here, we evaluate the role of calcium influx through voltage-gated calcium channels (VGCCs) ...
Bringing bioelectricity to light: all-optical electrophysiology using microbial rhodopsins
(2014-10-21)
My work has focused on the development and application of fluorescent voltage-sensitive proteins based on microbial rhodopsins. These probes led to the discovery of electrical activity in the bacterium Escherichia coli, ...
Engineering microbial rhodopsins to expand the optogenetic toolkit
(2014-10-21)
Cellular lipid membranes can – and often do – support a transmembrane electric field, serving as biological capacitors that maintain a voltage difference between their two sides. It isn't hard to see why these ...