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Investigating the Roles of IRF6 in Epithelial Maturation, Craniofacial Development, and Orofacial Cleft Pathogenesis
(2018-04-10)
Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...
Intergenerational Transmission of Non-Germline RNAs in Caenorhabditis Elegans
(2018-05-13)
In the model organism Caenorhabditis elegans, double-stranded RNA (dsRNA) capable of silencing genes can be introduced anywhere in the animal and will subsequently travel throughout the body and enter most cells, including ...
Mechanisms of Scale Invariance in Embryonic Patterning Systems
(2018-05-10)
Embryos pattern themselves with remarkable consistency and readily adjust their patterning programs to drastic changes in embryo size. This robustness of pattern formation, termed scale invariance, requires cells to determine ...
Temporal Regulation of Chromatin Organization During C. Elegans Embryogenesis
(2018-05-01)
In all eukaryotic cells, the genetic material is organized into a complex structure composed of DNA and protein: chromatin. Organization of chromatin structure in the nucleus influences all functions of the genome including ...
Investigating the Role of Heterogeneity in Breast Cancer and Experimental Design
(2018-08-31)
Breast cancer is predicted to be the most frequent newly diagnosed cancer and second leading cause of cancer-associated death among women in the United States in 2018. Intratumoral heterogeneity plays an important role in ...