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Elucidating the Functions of CDK8 and CDK19 in Acute Myeloid Leukemia
Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...
Molecular Mechanisms of the Formation and Maintenance of the Tubular Endoplasmic Reticulum Network
Membrane-bound organelles, a defining feature of eukaryotic cells, display a diverse set of characteristic shapes that range from highly spherical, to flattened sheets, and even thin tubules. Therefore, how the characteristic ...
Large-Scale Studies of the Protein Biochemistry Regulating Meiotic Exit and Fertilization
Dynamic post-translational modifications are central to coordinating complex biological processes. This is especially evident after fertilization, where the modification or destruction of the egg’s existing proteins is ...
Large-Scale Analysis of Microtubule Pharmacology via Phosphoproteomics and High-Content Imaging
The dynamic instability of microtubules is a critical phenomenon that regulates several biological processes. Chemical perturbation of microtubules disrupts these processes and is known to stimulate phosphorylation of ...