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Investigating the Roles of IRF6 in Epithelial Maturation, Craniofacial Development, and Orofacial Cleft Pathogenesis
(2018-04-10)
Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...
Genetic Basis of Natural Variation in Cellular Decision Making in Wild Yeasts
(2018-05-15)
In nature, microbes often need to decide which of many potential nutrients to consume. This decision-making process is complex, involving both intracellular constraints and the organism’s perception of the environment. ...
Intergenerational Transmission of Non-Germline RNAs in Caenorhabditis Elegans
(2018-05-13)
In the model organism Caenorhabditis elegans, double-stranded RNA (dsRNA) capable of silencing genes can be introduced anywhere in the animal and will subsequently travel throughout the body and enter most cells, including ...
The Design and Characterization of Bifunctional Degraders of TRIM24, a Novel Transcriptional Dependency in Hematologic Malignancies
(2018-04-24)
Transcriptional control is critical to the proper functioning of cells, their growth, differentiation, and survival. Because genomic and epigenomic alterations can deregulate transcription and promote an oncogenic state, ...
Temporal Regulation of Chromatin Organization During C. Elegans Embryogenesis
(2018-05-01)
In all eukaryotic cells, the genetic material is organized into a complex structure composed of DNA and protein: chromatin. Organization of chromatin structure in the nucleus influences all functions of the genome including ...
Directed evolution of Cas9 for mammalian genome editing
(2018-05-14)
The ability to manipulate the genome has been a longstanding goal since the discovery of the central dogma of molecular biology. Such a technology would not only allow us to correct deleterious mutations for human therapeutics ...
Causality in Epigenetics: Strategies for Targeted Epigenome Engineering of Transcriptional Regulation and Genome Topology
(2018-05-14)
Changes in epigenetic states are at the heart of normal developmental processes and also underlie many human diseases. Studies to date have established strong associations between histone post-translational modifications, ...
Programming molecular behavior: development and applications of autonomous DNA synthesis cascades
(2018-09-25)
DNA serves many functional roles in living organisms, and dynamic DNA nanotechnology seeks to expand this set of DNA-based behaviors through the rational design of new functions. In the past 20 years, the predictable and ...