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Directed evolution of Cas9 for mammalian genome editing
The ability to manipulate the genome has been a longstanding goal since the discovery of the central dogma of molecular biology. Such a technology would not only allow us to correct deleterious mutations for human therapeutics ...
Glycomic regulation of human B cells
All leukocytes are coated with a dense layer of carbohydrates called the glycocalyx. Initially believed to serve largely biophysical roles, the glycocalyx is increasingly recognized as a gatekeeper of leukocyte interactions ...