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Investigation of KRAS Dependency Bypass and Functional Characterization of All Possible KRAS Missense Variants
The importance of oncogenic KRAS in human cancers have prompted intense efforts to target KRAS and its effectors. To anticipate the development of resistance to these strategies, we previously performed a genome-scale ...
Causality in Epigenetics: Strategies for Targeted Epigenome Engineering of Transcriptional Regulation and Genome Topology
Changes in epigenetic states are at the heart of normal developmental processes and also underlie many human diseases. Studies to date have established strong associations between histone post-translational modifications, ...