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Statistical Methods for Evidence Synthesis
(2018-08-31)
In many empirical disciplines, scientific discovery is modularized into discrete papers each investigating one or more hypotheses. Synthesizing these modules of evidence is critical to inform a balanced and appropriately ...
Leveraging Functional Annotations and Multiethnic Data to Improve Polygenic Risk Prediction
(2018-09-25)
Polygenic risk prediction is a widely-investigated topic because of its potential clinical application as well as its utility to have a better understanding of the genetic architecture of complex traits. Methods to perform ...
Robust Methods for Estimating the Intraclass Correlation Coefficient and for Analyzing Recurrent Event Data
(2018-09-25)
Robust statistics have emerged as a family of theories and techniques for estimating parameters of a model while dealing with deviations from idealized assumptions. Examples of deviations include misspecification of ...
Statistical Methods for Assessing Complex Multi-Exposure Data in HIV and Genetic Epidemiology
(2018-05-16)
Complex, multi-exposure problems arise in many forms. In this dissertation, we delve into three disparate forms of complex, multi-exposure questions, from the safety of combination antiretroviral (ARV) regimens to the ...
Methods for Estimating the Health Effects of Exposure to Point Sources of Emissions Using Large-Scale and Diverse Data Sources
(2018-04-30)
There is a well-documented association between exposure to fine particulate matter (PM2.5) and numerous health outcomes, with some evidence suggesting PM2.5 originating from coal combustion may have different health impacts. ...