The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. We and others have previously shown that superpositively charged proteins are ...

Macrocyclic natural products occupy a special niche in the small molecule chemical space. Compared with other classes of small molecules, their larger size and conformational flexibility confer a higher propensity to ...

Research and innovation in recent years has led to a paradigm shift in the bioengineering community regarding biofilms. Rather than focusing on their negative impact in disease and materials fouling, we, and other groups, ...

Many cellular signaling pathways exhibit a bowtie topology: multiple distinct signal inputs converge on a single master transcription factor, which controls the expression of downstream genes. Recent evidence suggests that ...

Nucleophosmin (NPM1) is a multifunctional phosphoprotein localized predominantly within the nucleoli of eukaryotic cells. Mutations within its C-terminal domain are frequently observed in patients with acute myeloid leukemia ...

Insulin-Degrading Enzyme (IDE) is a zinc-metalloprotease responsible for the clearance of insulin in peripheral tissues. Despite decades of speculation that inhibiting endogenous insulin degradation might treat Type-2 ...

Traditionally the two major classes of drugs, small molecules and biologics, have been extensively used in drug discovery. However, it is difficult to inhibit protein-protein interactions with small molecules, and targets ...

The surface of Gram-negative bacteria is largely composed of lipopolysaccharide (LPS), a complex glycolipid that contains multiple fatty acyl chains and up to hundreds of sugars. LPS is transported from its site of synthesis ...