Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...

The chromosomal passenger complex (CPC) is a conserved protein complex regulating cell division. Although the kinase subunit, Aurora B (AURKB), self-activates through autophosphorylation, it remains unclear how this happens ...

Many cellular signaling pathways exhibit a bowtie topology: multiple distinct signal inputs converge on a single master transcription factor, which controls the expression of downstream genes. Recent evidence suggests that ...