Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...

Bacteria have developed resistance mechanisms to every class of antibiotics that has been created and combating the rise of multidrug-resistant bacteria—a major threat to public health—requires the continual development ...

Cellular DNA is under constant threat of reactive oxygen species (ROS) produced by either endogenous or exogenous sources. One of the major forms of DNA damages caused by ROS is 8-oxoguanine (oxoG), which is highly mutagenic, ...

Many cellular signaling pathways exhibit a bowtie topology: multiple distinct signal inputs converge on a single master transcription factor, which controls the expression of downstream genes. Recent evidence suggests that ...