Search
Now showing items 1-2 of 2
Therapeutic potential and physiological roles of Insulin-Degrading Enzyme illuminated by a DNA-templated macrocyclic inhibitor
(2015-05-19)
Insulin-Degrading Enzyme (IDE) is a zinc-metalloprotease responsible for the clearance of insulin in peripheral tissues. Despite decades of speculation that inhibiting endogenous insulin degradation might treat Type-2 ...
Inhibition of Metabolic Enzymes as Differentiation Therapy in Acute Myeloid Leukemia
(2017-01-26)
Acute myeloid leukemia (AML) is among the deadliest of cancers: it carries a 27% 5-year survival rate and is responsible for over 10,000 deaths annually in the United States alone. Despite the clear medical need, new ...