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Progress Toward the Total Synthesis of Vinigrol and Hibarimicin B
(2014-02-25)
Vinigrol is a structurally unique diterpenoid natural product featuring a tricyclo[4.4.4.0.4a,8a]tetradecene carbon skeleton containing eight contiguous stereocenters and a challenging oxygenation pattern. Vinigrol has ...
Total Synthesis of Hyperforin
(2013-10-17)
Hyperforin is the component of the medicinal herb St. John's Wort (Hypericum perforatum) responsible for its antidepressant activity. It works by blocking the reuptake of a variety of neurotransmitters through a unique ...
Total Syntheses of Fastigiatine and the Hibarimicin Aglycons
(2013-10-07)
Part one of this two-part thesis describes my efforts toward the total syntheses of the complex polycyclic alkaloids himeradine A and fastigiatine, which are members of the Lycopodium family of natural products. A cascade ...