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Targeting FGFR to Overcome EMT-Related Resistance to EGFR Inhibition in EGFR-Mutated Non-Small Cell Lung Cancer
(2018-01-19)
Acquired drug resistance to tyrosine kinase inhibitor (TKI) targeted therapies remains a major clinical challenge. In EGFR mutant non-small cell lung cancer (NSCLC), therapeutic failure of EGFR TKIs can result from both ...
Large-Scale Studies of the Protein Biochemistry Regulating Meiotic Exit and Fertilization
(2018-05-13)
Dynamic post-translational modifications are central to coordinating complex biological processes. This is especially evident after fertilization, where the modification or destruction of the egg’s existing proteins is ...
Investigating the Roles of IRF6 in Epithelial Maturation, Craniofacial Development, and Orofacial Cleft Pathogenesis
(2018-04-10)
Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...
Glycomic regulation of human B cells
(2018-09-16)
All leukocytes are coated with a dense layer of carbohydrates called the glycocalyx. Initially believed to serve largely biophysical roles, the glycocalyx is increasingly recognized as a gatekeeper of leukocyte interactions ...
Skeletal Muscle Macrophages: Characterization and Regulation by Regulatory T Cells
(2018-01-12)
Skeletal muscle regeneration is a highly orchestrated process that relies heavily on the immune system. Efficient regeneration post-acute injury requires both F4/80+ macrophages (MFs) and CD4+Foxp3+ T regulatory (Treg) ...
Investigation of KRAS Dependency Bypass and Functional Characterization of All Possible KRAS Missense Variants
(2018-05-11)
The importance of oncogenic KRAS in human cancers have prompted intense efforts to target KRAS and its effectors. To anticipate the development of resistance to these strategies, we previously performed a genome-scale ...
Regulation of Transcytosis Underlies Blood-Brain Barrier Permeability
(2018-01-08)
The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is essential for proper neural function. A single layer of continuous endothelial cells lining the walls of central nervous system (CNS) ...
Mechanisms of Scale Invariance in Embryonic Patterning Systems
(2018-05-10)
Embryos pattern themselves with remarkable consistency and readily adjust their patterning programs to drastic changes in embryo size. This robustness of pattern formation, termed scale invariance, requires cells to determine ...
Investigating the Role of Heterogeneity in Breast Cancer and Experimental Design
(2018-08-31)
Breast cancer is predicted to be the most frequent newly diagnosed cancer and second leading cause of cancer-associated death among women in the United States in 2018. Intratumoral heterogeneity plays an important role in ...
Activation and Antagonism of RIG-I-Mediated Innate Immune Signaling by Herpes Simplex Virus 1
(2018-01-16)
The cytosolic innate immune receptor retinoic acid-inducible gene-I (RIG-I) recognizes double-stranded RNA (dsRNA) that emerges during viral infection and initiates an antiviral response comprised of interferon (IFN) and ...