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Lin28a/b in the Regulation of Developmental Timing and Tumorigenesis
(2016-05-10)
The heterochronic genes Lin28a/b and let-7 have long been known to play critical roles in the development of organisms from worms to humans. These highly conserved genes have emerged as factors that regulate self-renewal, ...
Targeting FGFR to Overcome EMT-Related Resistance to EGFR Inhibition in EGFR-Mutated Non-Small Cell Lung Cancer
(2018-01-19)
Acquired drug resistance to tyrosine kinase inhibitor (TKI) targeted therapies remains a major clinical challenge. In EGFR mutant non-small cell lung cancer (NSCLC), therapeutic failure of EGFR TKIs can result from both ...
Molecular Details and Functional Analysis of RNA Binding by ESCRT-II
(2015-05-18)
Many RNAs show distinct localization patterns in cells with enrichment at particular subcellular sites or organelles. RNA localization is a highly conserved process that both spatially and temporally controls gene expression. ...
Glycomic regulation of human B cells
(2018-09-16)
All leukocytes are coated with a dense layer of carbohydrates called the glycocalyx. Initially believed to serve largely biophysical roles, the glycocalyx is increasingly recognized as a gatekeeper of leukocyte interactions ...
Investigating the Role of Heterogeneity in Breast Cancer and Experimental Design
(2018-08-31)
Breast cancer is predicted to be the most frequent newly diagnosed cancer and second leading cause of cancer-associated death among women in the United States in 2018. Intratumoral heterogeneity plays an important role in ...