Development is the elegant and complex process by which a single celled embryo grows into a fully formed and functional adult. One of the major challenges in the process of development is that although each cell in an ...

Despite nearly complete understanding of the genetics of the β-hemoglobinopathies for several decades, definitive treatment options have lagged behind. Fetal hemoglobin (HbF) reinduction represents a “silver bullet” for ...

The human brain can be affected by many diseases during its development, and human genetics studies can illuminate the genetic etiology of these diseases, which is critical for understanding disease pathophysiology, improving ...

The monoaminergic neuromodulatory systems (including the noraderenergic, serotonergic, and dopaminergic neuronal systems) have long been thought of as the custodians of mental health. Dysfunction amongst these neural ...

Since their divergence from a common ancestor some 200 million years ago, mammals have undergone significant diversification in physiology, morphology, habitat, size, and longevity. The maximum lifespan of mammalian species ...

Genetics is an incredibly powerful tool for interrogating human biology, as it allows us to identify genes influencing biological processes and diseases in a hypothesis-free manner and in the context of the human body. The ...

Tendons transmit force from muscle to bone, enabling movement; ligaments connect bone to bone, maintaining stability. Despite their importance, tendon and ligament development is relatively uncharacterized. In this ...

Animals switch between periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. C. elegans exhibit periods of behavioral quiescence during larval molts (termed lethargus) ...

The comprehensive identification of genetic alterations is critical to understanding the pathophysiology of cancer. Recent advances in sequencing technology have enabled the detailed description of cancer genomes. However, ...

A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...