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Regulation of the Inflamed Tumor Phenotype in Melanoma Immunotherapy
(2016-05-02)
Immune checkpoint inhibitors targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1) pathways can deliver durable anti-tumor effects. However, a major fraction of metastatic cancer ...
Skeletal Muscle Macrophages: Characterization and Regulation by Regulatory T Cells
(2018-01-12)
Skeletal muscle regeneration is a highly orchestrated process that relies heavily on the immune system. Efficient regeneration post-acute injury requires both F4/80+ macrophages (MFs) and CD4+Foxp3+ T regulatory (Treg) ...