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In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy
(2017-10-10)
Despite the dramatic clinical success of cancer immunotherapy with PD-1 checkpoint blockade, most patients do not experience sustained clinical benefit from treatment, suggesting that additional therapeutic strategies are ...
Regulation of the Inflamed Tumor Phenotype in Melanoma Immunotherapy
(2016-05-02)
Immune checkpoint inhibitors targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1) pathways can deliver durable anti-tumor effects. However, a major fraction of metastatic cancer ...
IAP Inhibitors as Novel Immune Adjuvants for Scaffold Based Cancer Vaccines
(2015-05-14)
Inhibitors of apoptosis (IAP) antagonists are nearing approval as promising new candidates for cancer therapy, particularly for solid tumors. Previous work had uncovered the ability of the monomer version of this drug to ...