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Mycobacterial Metabolic Syndrome: Triglyceride Accumulation Decreases Growth Rate and Virulence of Mycobacterium Tuberculosis
Mycobacterium tuberculosis (Mtb) mutants lacking the operon Rv1411c-1410c encoding a lipoprotein, Rv1411c (LprG) and a putative transporter, Rv1410c (Rv1410) are dramatically attenuated for growth in mice. Previous work ...
Spatiotemporal Control of Mycobacterium Tuberculosis Cell Wall Biogenesis by the Peptidoglycan Synthase PonA1
Mycobacterium tuberculosis causes one of the most pernicious infectious diseases of humankind – tuberculosis, which is still a global problem in the 21st century. Drug-resistant M. tuberculosis infections are on the rise, ...
Enterococcus infection of Caenorhabditis elegans as a model of innate immunity
The vast majority of metazoan species are invertebrates, which lack an adaptive immune system for defense against microbes. Instead, their innate immune system is sufficient for defense against pathogenic organisms, which ...
A sigma factor and anti-sigma factor that control swarming motility and biofilm formation in Pseudomonas aeruginosa
Pseudomonas aeruginosa is an environmental bacterium and opportunistic human pathogen of major clinical significance. It is the principal cause of morbidity and mortality in patients with cystic fibrosis (CF) and a leading ...