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Coupling the small GTPase Rab3 to the Synaptic Vesicle Cycle
(2013-10-08)
Coupling the small GTPase Rab3 to the Synaptic Vesicle Cycle
Modeling sporadic Alzheimer's disease using induced pluripotent stem cells
(2014-10-22)
Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation ...
Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network
(2021-07-12)
Behavioral experiences activate the Fos transcription factor in sparse populations of neurons that are critical for encoding and recalling specific events. However, there is limited understanding of the mechanisms by which ...
Molecular and cellular mechanisms underlying adult blood-brain barrier maintenance
(2022-01-20)
To ensure optimal neuronal function, the blood-brain barrier (BBB) maintains a homeostatic brain microenvironment free from harmful agents and delivers nutrients to the brain to support metabolic needs. Although the BBB ...
A Molecular Trigger for Sea Anemone Stinging
(2021-05-17)
Understanding the mechanisms by which cells detect, integrate, and respond to distinct sensory cues is of fundamental importance to biological systems. Cnidarians, such as jellyfish, hydroids, and sea anemones, use specialized ...
Building in vitro human iPSC-derived motor neuron systems to explore cell autonomous mechanisms and modifiers of TDP-43 perturbation associated neurotoxicity
(2024-01-22)
Transactive Response DNA Binding Protein 43 (TDP-43) is a ubiquitously expressed nucleic acid transport and processing factor that is essential for normal cellular development and function. Disruptions to TDP-43 function ...