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Functional and genomic analysis of MEF2 transcription factors in neural development
(2014-10-21)
Development of the central nervous system requires the precise coordination of intrinsic genetic programs to instruct cell fate, synaptic connectivity and function. The MEF2 family of transcription factors (TFs) plays many ...
Modeling sporadic Alzheimer's disease using induced pluripotent stem cells
(2014-10-22)
Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation ...