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Promoter Decoding of Transcription Factor Translocation Dynamics
(2015-05-11)
Many cellular signaling pathways exhibit a bowtie topology: multiple distinct signal inputs converge on a single master transcription factor, which controls the expression of downstream genes. Recent evidence suggests that ...
Elucidating the Functions of CDK8 and CDK19 in Acute Myeloid Leukemia
(2018-04-19)
Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...