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Interplay of Dengue Virus and the Human Immune Response
(2015-05-07)
RIG-I is a key cytosolic sensor of many RNA viruses, including dengue virus (DV), the most significant arboviral pathogen. Upon viral RNA binding, RIG-I signals via the adaptor protein MAVS, located at mitochondria, to ...
TRIM22 IS A NOVEL RESTRICTION FACTOR OF HERPESVIRUSES
(2015-05-13)
The host response to the family of nuclear replicating DNA viruses or the herpesviruses includes the intrinsic, innate and adaptive arms of the immune system. Intrinsic resistance is a constitutively active line of defense ...